Doctor 's Best, Mejor lumbrokinase, 20 mg, 60 Cápsulas, 903298, 1, 1
- Product Code: 1567768218-5774
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$ 99.94
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1.- Tiempo de entrega de 3 a 5 días Hábiles.
2.- Enviamos su compra a cualquier parte del país.
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***** TITULO COMPLETO *****
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Doctor 's Best, Mejor lumbrokinase, 20 mg, 60 Cápsulas, 903298, 1, 1.
***** DESCRIPCIÓN DEL PRODUCTO *****
.
. Más información del producto Leer más *These statements have not been evaluated by the Food and Drug Administration. This product in not intended to diagnose, treat, cure or prevent any disease. Doctor’s Best Lumbrokinase is a group of highly stable fibrinolytic enzymes that have been studied and utilized extensively in China for many years. Research suggests that Lumbrokinase may have beneficial effects on the cardiovascular system*. Lumbrokinase is a highly active form of this enzyme group and may be used to support and maintain healthy cardiovascular function* Leer más What are the benefits of Lumbrokinase? - Supports cardiovascular health* - Helps to lower fibrin levels* - Helps to lower blood viscosity* Why take Lumbrokinase? - Lumbrokinase provides enzymatic support to help maintain cardiovascular function.* - Breaks down proteins facilitating the removal of cell debris.* How does it work? - Lumbrokinase is the name of a group of highly stable fibrinolytic enzymes. These proteolytic enzymes have been studied and utilized extensively in China for many years.* - Research suggests that lumbrokinase may have beneficial effects on the cardiovascular system.* Fibrinolytic enzymes are essential enzymes that break down excess fibrin in the body. These enzymes eliminate excess fibrin that that forms scar tissue inside blood vessels, kidneys and brain as well as in muscles.* Leer más Leer más Lumbrokinase helps to maintain healthier blood, lower blood viscosity and support cardiovascular health.* In many Asian cultures, the use of earthworms in traditional medicine is quite common. Hundreds of years ago, Shizhen Li compiled the famous medical book Compendium of Material, in which the earthworm (Earth dragon) was listed as a remedy for high fever and diuretic purposes in the form of a dried powder.2 This remedy is still used in Chinese folk medicine. To meet the high demand for more natural solutions to support one’s circulatory health, bioactive components from earthworms have been studied all around the world. Because earthworms are widely used in Asian cultures, most of the scientific research on earthworms have been originated from China, Korea and Japan. The results of these studies summarized in several articles show that earthworms' extracts contain a complex enzymatic group known as lumbrokinase that has potent fibrinolytic activity. Lumbrokinase is a group of proteolytic enzymes which are able to dissolve fibrin, a protein which is involved in the coagulation of blood clots. Lumbrokinase has been shown to be safe for oral consumption in humans.3, 4, 5 Advances in the development of molecular and cellular biology techniques have greatly helped biologists to analyze the underlying molecular basis of lumbrokinase extracts. Lumbrokinase has a thrombolytic effect that may improve blood circulation*.6, 7 It has been shown to be an effective oral supplement for improving circulatory health.*8, 9 Pharmacological And Clinical Studies: Elevated fibrinogen level is a known risk factor that reflects a problem affecting blood flow and consequently leading to heart problems. A study was conducted to observe the efficacy of one-year oral lumbrokinase enteric-coated capsules: 192 participants in the treatment group were given 600,000 units lumbrokinase, three times a day, 30 minutes before meals, and 118 participants in the control group were given placebo capsules). After 1 year of treatment, the researchers found that in the treatment group, fibrinogen level was lower and blood flow was improved. These benefits may be related to the fact that lumbrokinase has selective affinity for fibrinogen and directly hydrolyzes fibrinogen to soluble fibrinogen degradation products improving blood and plasma viscosity. Based on the study, lumbrokinase may have an anti-platelet effect through the elevation of cAMP level and Ca2+ release.10 A Japanese research team investigated the pharmacological activity of pure extracts of an earthworm, Lumbricus rubellus. They discovered that the earthworm has fibrinolytic activity that is made of six different fibrinolytic isoenzymes. These enzymes were collectively named lumbrokinase after the genus name for earthworm, Lumbricus.11 Among those isoenzymes, EFE-III-1 and III-2, had strong fibrinolytic activities, broad pH optima (pH 9-11) and displayed resistance to thermal denaturation. Further studies show that lumbrokinase has trypsin-like characteristics with high substrate specificity against fibrin, which may make it suitable as a fibrinolytic agent.12, 13, 14 These results seem to suggest that lumbrokinase could potentially be an effective oral supplement in helping maintain a healthy blood state.* A clinical study, involving 51 participants, was conducted to investigate the anticoagulation effect and fibrinolytic activity of lumbrokinase in humans. These participants were randomly divided into treatment group (n = 31) and control group (n = 20). Among other parameters, prothrombin time (PT), fibrinogen content, tissue plasminogen activator (t-PA) activity, plasminogen activator inhibitor (PAI) activity, and D-dimer level were assayed. In the treatment group, t-PA activity and D-dimer level increased, while the content of fibrinogen decreased significantly. There were no significant changes of PT and PAI activity in both groups. The researchers concluded that lumbrokinase is beneficial in lowering fibrinogen levels*. The effect of lumbrokinase may be related to the inhibition of intrinsic coagulation pathway and the activation of fibrinolysis via an increase of t-PA activity.6 In a study conducted at Beijing Tongren Hospital, participants with high levels of fibrinogen were given lumbrokinase tablets to take orally every day for three weeks. Serum fibrinogen levels were examined before and after treatment. In comparison with the control group, serum fibrinogen in the lumbrokinase group significantly decreased two weeks after treatment. These results demonstrated lumbrokinase may lower blood viscosity. Moreover, there were no side effects related to the intake of lumbrokinase.15 A clinical study was conducted which attempted to compare a control group (12 participants which did not take lumbrokinase) and a lumbrokinase group (12 participants that were given 2 capsules three times daily of lumbrokinase). The group that received lumbrokinase showed a decrease in blood viscosity after only three weeks. The lumbrokinase group also had significantly reduced fibrinogen which resulted in fibrinolysis, a breakdown of blood clots. This study reinforces the effect of lumbrokinase on blood circulation.*16 A study in rats was conducted to evaluate the effects of lumbrokinase-containing earthworm powder on induced thrombotic blood clots in vivo. The powder was administered orally to rats and its fibrinolytic and antithrombotic effects were investigated. The fibrinolytic activity of plasma was increased to two-folds of the control at a dose of 0.5 g/kg/day and five times with 1 g/kg/day after 4-day administration. The antithrombotic effect was studied in an arterio-venous shunt model of rats. The weight of the blood clots decreased significantly from 43.2 mg to 32.4 mg at a dose of 0.5 g/kg/day after 8-day treatment. These results support that lumbrokinase-containing earthworm powder is valuable in maintaining healthy blood flow.*17 *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Scientific References: 1. Sinha RK, Chauhan K, Valani D and al. Earthworms: Charles Darwin's 'unheralded soldiers of mankind': Protective & productive for man & environment. Journal of Environmental Protection. 2010;1: 251-260. 2. Li W, Wang C and Sun Z. Vermipharmaceuticals and active proteins isolated from earthworms. Pedobiologia. 2011; 54S:S49– S56. 3. Cooper EL. New enzyme complex isolated from earthworms is potent fibrinolytic: lumbrokinase has anti-platelet, anti-thrombotic activity. In Focus: Allergy Research Group Newsletter. March 2009:2–5. 4. Cooper EL and Balamurugan M. Unearthing a source of medicinal molecules. Drug Discovery Today. 2010; 15: 966-972. 5. Karaca A. Biology of earthworms. 2011. Soil biology. Vol 24. Published by Springer-Verlag Berlin Heidelberg. 6. Jin L, Jin H, Zhang G et al. Changes in coagulation and tissue plasminogen activator after the treatment of cerebral infarction with lumbrokinase. Clin Hemorheol Microcirc. 2000; 23:213–218. 7. Trisina J, Sunardi F, Suhartono MT et al. DLBS1033, a protein extract from Lumbricus rubellus, possesses antithrombotic and thrombolytic activities. J Biomed Biotech. 2011; 7 pages. 8. Fan Q, Wu C, Fan R et al. Some features of intestinal absorption of intact fibrinolytic enzyme III-1 from Lumbricus rubellus. Biochimica et Biophysica Acta 1526. 2001:286-292. 9. Yan XM, Kim CH, et al. Intestinal absorption of fibrinolytic and proteolytic lumbrokinase extracted from earthworm, Eisenia andrei. Korean J Physiol Pharmacol. 2010; 14:71-75 10. Cao YJ, Zhang X, Wang WH et al. Oral fibrinogen-depleting agent lumbrokinase for secondary ischemic stroke prevention: results from a multicenter, randomized, parallel group and controlled clinical trial. Chin Med J. 2013; 21:4060-4065. 11. Mihara H, Sumi H, Yoneta T et al. A novel fibrinolytic enzyme extracted from the earthworm, Lumbricus rubellus. Japanese J Physiol. 1991; 41:461-472. 12. Nakajima N, Mihara H et Sumi H. Characterization of potent fibrinolytic enzymes in earthworm, Lumbricus rubellus. Biosci Biotech Biochem. 1993; 57:1726-1730. 13. Park YD, Kim JW, Min BG et al. Rapid purification and biochemical characteristics of lumbrokinase III from earthworm for use as a fibrinolytic agent. Biotech Letters. 1998; 20:169-172. 14. Cho IH, Choi ES, Lim HG et al. Purification and characterization of six fibrinolytic serine-proteases from earthworm Lumbricus rubellus. J Biochem Mol Biol. 2004; 37:199-205. 15. Gao Y, Qin MZ. Lumbrokinase in treatment of patients with hyperfibrinogenemia of coronary atherogenesis disease. Journal of Capital University of Medical Sciences, 1999; 4(20) 16. Zhang JQ and Jin CH. Clinical observation of using Baiao Lumbrokinase in the treatment of central retinal vein occlusion. Capital Medicine. 1999, 6(2): 51 17. Kim YS, Pyo MK, Park KM et al. Dose dependency of earthworm powder on antithrombotic and fibrinolytic effects. Arch. Pharm. Res. 1998; 21:374-377. Leer más . Descripción del producto Tamaño:paquete de de 1 Doctor de la mejor, mejor lumbrokinase, 20 mg, 60 Cápsulas .
1.- Tiempo de entrega de 3 a 5 días Hábiles.
2.- Enviamos su compra a cualquier parte del país.
.
.
***** TITULO COMPLETO *****
.
Doctor 's Best, Mejor lumbrokinase, 20 mg, 60 Cápsulas, 903298, 1, 1.
***** DESCRIPCIÓN DEL PRODUCTO *****
.
. Más información del producto Leer más *These statements have not been evaluated by the Food and Drug Administration. This product in not intended to diagnose, treat, cure or prevent any disease. Doctor’s Best Lumbrokinase is a group of highly stable fibrinolytic enzymes that have been studied and utilized extensively in China for many years. Research suggests that Lumbrokinase may have beneficial effects on the cardiovascular system*. Lumbrokinase is a highly active form of this enzyme group and may be used to support and maintain healthy cardiovascular function* Leer más What are the benefits of Lumbrokinase? - Supports cardiovascular health* - Helps to lower fibrin levels* - Helps to lower blood viscosity* Why take Lumbrokinase? - Lumbrokinase provides enzymatic support to help maintain cardiovascular function.* - Breaks down proteins facilitating the removal of cell debris.* How does it work? - Lumbrokinase is the name of a group of highly stable fibrinolytic enzymes. These proteolytic enzymes have been studied and utilized extensively in China for many years.* - Research suggests that lumbrokinase may have beneficial effects on the cardiovascular system.* Fibrinolytic enzymes are essential enzymes that break down excess fibrin in the body. These enzymes eliminate excess fibrin that that forms scar tissue inside blood vessels, kidneys and brain as well as in muscles.* Leer más Leer más Lumbrokinase helps to maintain healthier blood, lower blood viscosity and support cardiovascular health.* In many Asian cultures, the use of earthworms in traditional medicine is quite common. Hundreds of years ago, Shizhen Li compiled the famous medical book Compendium of Material, in which the earthworm (Earth dragon) was listed as a remedy for high fever and diuretic purposes in the form of a dried powder.2 This remedy is still used in Chinese folk medicine. To meet the high demand for more natural solutions to support one’s circulatory health, bioactive components from earthworms have been studied all around the world. Because earthworms are widely used in Asian cultures, most of the scientific research on earthworms have been originated from China, Korea and Japan. The results of these studies summarized in several articles show that earthworms' extracts contain a complex enzymatic group known as lumbrokinase that has potent fibrinolytic activity. Lumbrokinase is a group of proteolytic enzymes which are able to dissolve fibrin, a protein which is involved in the coagulation of blood clots. Lumbrokinase has been shown to be safe for oral consumption in humans.3, 4, 5 Advances in the development of molecular and cellular biology techniques have greatly helped biologists to analyze the underlying molecular basis of lumbrokinase extracts. Lumbrokinase has a thrombolytic effect that may improve blood circulation*.6, 7 It has been shown to be an effective oral supplement for improving circulatory health.*8, 9 Pharmacological And Clinical Studies: Elevated fibrinogen level is a known risk factor that reflects a problem affecting blood flow and consequently leading to heart problems. A study was conducted to observe the efficacy of one-year oral lumbrokinase enteric-coated capsules: 192 participants in the treatment group were given 600,000 units lumbrokinase, three times a day, 30 minutes before meals, and 118 participants in the control group were given placebo capsules). After 1 year of treatment, the researchers found that in the treatment group, fibrinogen level was lower and blood flow was improved. These benefits may be related to the fact that lumbrokinase has selective affinity for fibrinogen and directly hydrolyzes fibrinogen to soluble fibrinogen degradation products improving blood and plasma viscosity. Based on the study, lumbrokinase may have an anti-platelet effect through the elevation of cAMP level and Ca2+ release.10 A Japanese research team investigated the pharmacological activity of pure extracts of an earthworm, Lumbricus rubellus. They discovered that the earthworm has fibrinolytic activity that is made of six different fibrinolytic isoenzymes. These enzymes were collectively named lumbrokinase after the genus name for earthworm, Lumbricus.11 Among those isoenzymes, EFE-III-1 and III-2, had strong fibrinolytic activities, broad pH optima (pH 9-11) and displayed resistance to thermal denaturation. Further studies show that lumbrokinase has trypsin-like characteristics with high substrate specificity against fibrin, which may make it suitable as a fibrinolytic agent.12, 13, 14 These results seem to suggest that lumbrokinase could potentially be an effective oral supplement in helping maintain a healthy blood state.* A clinical study, involving 51 participants, was conducted to investigate the anticoagulation effect and fibrinolytic activity of lumbrokinase in humans. These participants were randomly divided into treatment group (n = 31) and control group (n = 20). Among other parameters, prothrombin time (PT), fibrinogen content, tissue plasminogen activator (t-PA) activity, plasminogen activator inhibitor (PAI) activity, and D-dimer level were assayed. In the treatment group, t-PA activity and D-dimer level increased, while the content of fibrinogen decreased significantly. There were no significant changes of PT and PAI activity in both groups. The researchers concluded that lumbrokinase is beneficial in lowering fibrinogen levels*. The effect of lumbrokinase may be related to the inhibition of intrinsic coagulation pathway and the activation of fibrinolysis via an increase of t-PA activity.6 In a study conducted at Beijing Tongren Hospital, participants with high levels of fibrinogen were given lumbrokinase tablets to take orally every day for three weeks. Serum fibrinogen levels were examined before and after treatment. In comparison with the control group, serum fibrinogen in the lumbrokinase group significantly decreased two weeks after treatment. These results demonstrated lumbrokinase may lower blood viscosity. Moreover, there were no side effects related to the intake of lumbrokinase.15 A clinical study was conducted which attempted to compare a control group (12 participants which did not take lumbrokinase) and a lumbrokinase group (12 participants that were given 2 capsules three times daily of lumbrokinase). The group that received lumbrokinase showed a decrease in blood viscosity after only three weeks. The lumbrokinase group also had significantly reduced fibrinogen which resulted in fibrinolysis, a breakdown of blood clots. This study reinforces the effect of lumbrokinase on blood circulation.*16 A study in rats was conducted to evaluate the effects of lumbrokinase-containing earthworm powder on induced thrombotic blood clots in vivo. The powder was administered orally to rats and its fibrinolytic and antithrombotic effects were investigated. The fibrinolytic activity of plasma was increased to two-folds of the control at a dose of 0.5 g/kg/day and five times with 1 g/kg/day after 4-day administration. The antithrombotic effect was studied in an arterio-venous shunt model of rats. The weight of the blood clots decreased significantly from 43.2 mg to 32.4 mg at a dose of 0.5 g/kg/day after 8-day treatment. These results support that lumbrokinase-containing earthworm powder is valuable in maintaining healthy blood flow.*17 *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Scientific References: 1. Sinha RK, Chauhan K, Valani D and al. Earthworms: Charles Darwin's 'unheralded soldiers of mankind': Protective & productive for man & environment. Journal of Environmental Protection. 2010;1: 251-260. 2. Li W, Wang C and Sun Z. Vermipharmaceuticals and active proteins isolated from earthworms. Pedobiologia. 2011; 54S:S49– S56. 3. Cooper EL. New enzyme complex isolated from earthworms is potent fibrinolytic: lumbrokinase has anti-platelet, anti-thrombotic activity. In Focus: Allergy Research Group Newsletter. March 2009:2–5. 4. Cooper EL and Balamurugan M. Unearthing a source of medicinal molecules. Drug Discovery Today. 2010; 15: 966-972. 5. Karaca A. Biology of earthworms. 2011. Soil biology. Vol 24. Published by Springer-Verlag Berlin Heidelberg. 6. Jin L, Jin H, Zhang G et al. Changes in coagulation and tissue plasminogen activator after the treatment of cerebral infarction with lumbrokinase. Clin Hemorheol Microcirc. 2000; 23:213–218. 7. Trisina J, Sunardi F, Suhartono MT et al. DLBS1033, a protein extract from Lumbricus rubellus, possesses antithrombotic and thrombolytic activities. J Biomed Biotech. 2011; 7 pages. 8. Fan Q, Wu C, Fan R et al. Some features of intestinal absorption of intact fibrinolytic enzyme III-1 from Lumbricus rubellus. Biochimica et Biophysica Acta 1526. 2001:286-292. 9. Yan XM, Kim CH, et al. Intestinal absorption of fibrinolytic and proteolytic lumbrokinase extracted from earthworm, Eisenia andrei. Korean J Physiol Pharmacol. 2010; 14:71-75 10. Cao YJ, Zhang X, Wang WH et al. Oral fibrinogen-depleting agent lumbrokinase for secondary ischemic stroke prevention: results from a multicenter, randomized, parallel group and controlled clinical trial. Chin Med J. 2013; 21:4060-4065. 11. Mihara H, Sumi H, Yoneta T et al. A novel fibrinolytic enzyme extracted from the earthworm, Lumbricus rubellus. Japanese J Physiol. 1991; 41:461-472. 12. Nakajima N, Mihara H et Sumi H. Characterization of potent fibrinolytic enzymes in earthworm, Lumbricus rubellus. Biosci Biotech Biochem. 1993; 57:1726-1730. 13. Park YD, Kim JW, Min BG et al. Rapid purification and biochemical characteristics of lumbrokinase III from earthworm for use as a fibrinolytic agent. Biotech Letters. 1998; 20:169-172. 14. Cho IH, Choi ES, Lim HG et al. Purification and characterization of six fibrinolytic serine-proteases from earthworm Lumbricus rubellus. J Biochem Mol Biol. 2004; 37:199-205. 15. Gao Y, Qin MZ. Lumbrokinase in treatment of patients with hyperfibrinogenemia of coronary atherogenesis disease. Journal of Capital University of Medical Sciences, 1999; 4(20) 16. Zhang JQ and Jin CH. Clinical observation of using Baiao Lumbrokinase in the treatment of central retinal vein occlusion. Capital Medicine. 1999, 6(2): 51 17. Kim YS, Pyo MK, Park KM et al. Dose dependency of earthworm powder on antithrombotic and fibrinolytic effects. Arch. Pharm. Res. 1998; 21:374-377. Leer más . Descripción del producto Tamaño:paquete de de 1 Doctor de la mejor, mejor lumbrokinase, 20 mg, 60 Cápsulas .